どなたでも論文ゼミに参加可能ですので、参加を希望される方は小笠原までご連絡ください。
<2024年>
4月25日：永島
Bifidobacterium Longum Promotes Postoperative Liver Function Recovery in Patients with Hepatocellular Carcinoma.
Yu, Jingjing, Peng Zhu, Linlin Shi, Na Gao, Yani Li, Chang Shu, Ying Xu, et al.
Cell Host Microbe. 2024. 32 (1): 131–144. PMID 38091982
4月18日：中村
Efficacy of combined disinfection with a nitric oxide donor in controlling biofilm formation on the reverse osmosis water pathway for hemodialysis
Yoshihiro Tange, Ayane Murata, Shigenori Yoshitake
J Water Health. 2023 Oct;21(10):1591-1599. PMID: 37902212
4月4日：白石
Crucial Role for Lipoteichoic Acid Assembly in the Metabolic Versatility and Antibiotic Resistance of Staphylococcus aureus.
Burtchett TA, Shook JC, Hesse LE, Delekta PC, Brzozowski RS, Nouri A, Calas AJ, Spanoudis CM, Eswara PJ, Hammer ND.
Infect Immun. 2023 91(7):e0055022. PMID:37347167
3月21日：吉田(圭)
Prevention of respiratory virus transmission by resident memory CD8+ T cells.
Uddbäck I, Michalets SE, Saha A, Mattingly C, Kost KN, Williams ME, Lawrence LA, Hicks SL, Lowen AC, Ahmed H, Thomsen AR, Russell CJ, Scharer CD, Boss JM, Koelle K, Antia R, Christensen JP, Kohlmeier JE.
Nature. 2024 626(7998):392-400. PMID: 38086420
3月14日：吉田(有)
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H.
NPJ Vaccines. 2023 8(1):106. PMID: 37488116
3月7日：永島
Distinctive probiotic features share common TLR2-dependent signalling in intestinal epithelial cells.
Paveljšek D, Ivičak-Kocjan K, Treven P, Benčina M, Jerala R, Rogelj I.
Cell Microbiol. 2021 (1):e13264. PMID: 32945079
2月29日：山本
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM et al.
Nat Commun. 2024 15(1):1173. PMID: 38332002
2月15日：中村
Five-year trends in bacterial contamination of dialysis equipment
Osono E, Honda K, Inoue Y, Ichimura K, Kamano C, Kawamoto S, Norose Y, Takaku S, Morita R, Tsuchido T.
J Microorg Control. 2023 28(3). PMID: 37866898
2月1日：白石
The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance Lacotte PA, Denis-Quanquin S, Chatonnat E, Le Bris J, Leparfait D, Lequeux T, Martin-Verstraete I, Candela T.
Front Microbiol. 2023 14:1267662. PMID: 37965542
1月18日：小笠原
Early human lung immune cell development and its role in epithelial cell fate
Josephine L Barnes et al.,
Sci Immunol. 2023 Dec 15;8(90):eadf9988. doi: 10.1126/sciimmunol.adf9988. PMID: 38100545
1月11日：横田
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection.
Bagdonaite I, Marinova IN, Rudjord-Levann AM, Pallesen EMH, King-Smith SL, Karlsson R, Rømer TB, Chen YH, Miller RL, Olofsson S, Nordén R, Bergström T, Dabelsteen S, Wandall HH.
Nat Commun. 2023 Nov 2;14(1):7000. doi: 10.1038/s41467-023-42669-6. PMID: 37919266
<2023年>
12月21日：吉田(圭)
Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions.
El Najjar F, Castillo SR, Moncman CL, Wu CY, Isla E, Velez Ortega AC, Frolenkov GI, Cifuentes-Munoz N, Dutch RE.
mBio. 2023 14(5):e0158923. PMID: 37681946
12月14日：吉田(有)
Intranasal parainfluenza virus type 5 (PIV5)-vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study.
Spearman P, Jin H, Knopp K, Xiao P, Gingerich MC, Kidd J, Singh K, Tellier M, Radziewicz H, Wu S, McGregor M, Freda B, Wang Z, John SP, Villinger FJ, He B.
Sci Adv. 2023 9(43):eadj7611. PMID: 37878713
11月30日：永島
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling.
d'Hennezel E, Abubucker S, Murphy LO, Cullen TW.
mSystems. 2017 2(6):e00046-17. PMID: 29152585
11月16日：山本
Marie-Helene Corre et al., Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water ISME J, 2022, PMID:35545659
11月2日：小笠原
Xu Qin et al., Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
Nat Immunol. 2023, PMID:36536106
10月19日：谷向
Kleiner, V.A., O. Fischmann, T., Howe, J.A. et al.Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol 6, 649 (2023).
9月21日：山本
Respiratory syncytial virus ribonucleoproteins hijack microtubule Rab11 dependent transport for intracellular trafficking
Gina Cosentino, Katherine Marougka, Aurore Desquesnes, Nicolas Welti, Delphine Sitterlin, Elyanne Gault, Marie-Anne Rameix-Welti
PLoS Pathog. 2022;18(7):e1010619. PMID: 35797399
9月14日：吉田
Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage.
Li Z, Li B, Chen Z, Xu J, El Sabbagh A, Zhao Y, Du R, Rong L, Tian J, Cui Q.
J Med Virol. 2023 95(8):e29059. PMID: 37635463
9月7日：白石
Structure and Anti-Inflammation Potential of Lipoteichoic Acids Isolated from Lactobacillus Strains.
Lu Q, Guo Y, Yang G, Cui L, Wu Z, Zeng X, Pan D, Cai Z.
Foods. 2022 11(11):1610. PMID: 35681360
8月31日：中村
Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study. Eden G st al., Crit Care., 2022; 26(1):181. doi: 10.1186/s13054-022-04044-7. PMID: 35715801
8月24日：永島
Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
Francisco A, et al., Front Immunol. 2022 Jan 24;12:748303. doi: 10.3389/fimmu.2021.748303. eCollection 2021.
PMID: 35140704
8月3日：白石
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
Cancer Discov. 2017 7(5):522-538. PMID: 28202625.
7月27日：横田
Nei-like DNA glycosylase 2 (NEIL2) selectively antagonizes interferon-β expression upon respiratory syncytial virus infection.
Pan L, Xue Y, Wang K, Zheng X, Islam A, Tapryal N, Chakraborty A, Bacsi A, Ba X, Hazra TK, Boldogh I.
J Biol Chem. 2023 Jul 7:105028. doi: 10.1016/j.jbc.2023.105028. Online ahead of print. PMID: 37423306
7月20日:吉田
Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction
Suryawanshi RK, Patil CD, Agelidis A, Koganti R, Yadavalli T, Ames JM, Borase H, Shukla D.
Sci Adv. 2023 9(17):eadf3977. PMID: 37115924
7月13日:谷向
Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study
DeVincenzo J, Cass L, Murray A, Woodward K, Meals E, Coates M, Daly L, Wheeler V, Mori J, Brindley C, Davis A, McCurdy M, Ito K, Murray B, Strong P, Rapeport G.
J Infect Dis. 2022 25(12):2087-2096. PMID: 33216113
7月6日:山本
CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection
B Vijayalakshmi Ayyar, Khalil Ettayebi, Wilhelm Salmen, Umesh C Karandikar, Frederick H Neill, Victoria R Tenge, Sue E Crawford, Erhard Bieberich, B V Venkataram Prasad, Robert L Atmar, Mary K Estes
Nat Commun 2023 Feb 28;14(1):1148. PMID: 36854760
6月22日:横田
Oligopeptide Transporters of Nonencapsulated Streptococcus pneumoniae Regulate CbpAC and PspA Expression and Reduce Complement-Mediated Clearance.
Thompson CD, Bradshaw JL, Miller WS, Vidal AGJ, Vidal JE, Rosch JW, McDaniel LS, Keller LE.
mBio. 2023;14(1):e0332522. doi: 10.1128/mbio.03325-22. PMID: 36625598
6月15日:永島
Oster, Paul, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, et al. 2022. “Helicobacter Pylori Infection Has a Detrimental Impact on the Efficacy of Cancer Immunotherapies.” Gut 71 (3): 457–66.
PMID: 34253574
6月8日:谷向
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H.
Science. 2023 379(6632):586-591. PMID: 36758070.
6月1日:白石
Lipoteichoic Acid Inhibits Lipopolysaccharide-Induced TLR4 Signaling by Forming an Inactive TLR4/MD-2 Complex Dimer.
Watanabe S, Zenke K, Muroi M.
J Immunol. 2023. 210(9):1386-1395. PMID: 36897262
5月18日:吉田
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.
Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, Ting JP.
Cell Host Microbe. 2023. 31(2):243-259. PMID: 36563691
5月11日:永島
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister et al., Nature, 2021 Apr;592(7854):450-456.
PMID: 33762733
4月20日:山本
Norovirus MLKL-like protein initiates cell death to induce viral egress
Guoxun Wan, Di Zhang, Robert C Orchard , Dustin C Hancks, Tiffany A Reese
Nature, 2023, 16(7955):152-158, PMID: 36991121
4月6日:小笠原
Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics.
Schwartz M, Shnayder M, Nachshon A, Arazi T, Kitsberg Y, Levi Samia R, Lavi M, Kuint R, Tsabari R, Stern-Ginossar N. Nat Microbiol. 2023, 8(3):455-468.PMID: 36732471.
3月30日:白石
Yang H, Smith RD, Sumner KP, Goodlett DR, Johnson JK, Ernst RK.
A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens.
Microbiol Spectr. 2022. 10(6), PMID: 36255333
Yang H, Smith RD, Chandler CE, Johnson JK, Jackson SN, Woods AS, Scott AJ, Goodlett DR, Ernst RK.
Lipid A Structural Determination from a Single Colony.
Anal Chem. 2022. 94(21):7460-7465. PMID: 35576511
3月9日:谷向
Mao T, Israelow B, Peña-Hernández MA, Suberi A, Zhou L, Luyten S, Reschke M, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science. 2022 Nov 25;378(6622):eabo2523. doi: 10.1126/science.abo2523. Epub 2022 Nov 25. PMID: 36302057; PMCID: PMC9798903.
3月2日:吉田
Yannic C Bartsch, Deniz Cizmeci, Jaewon Kang, Tomer Zohar, Sivakumar Periasamy, Nickita Mehta, Jeroen Tolboom, Leslie Van der Fits, Jerry Sadoff, Christy Comeaux, Benoit Callendret, Alexander Bukreyev, Douglas A Lauffenburger, Arangassery Rosemary Bastian, Galit Alter
Antibody effector functions are associated with protection from respiratory syncytial virus
Cell. 2022, 185(26):4873-4886, PMID: 36513064
2月2日:山本
Dhiraj Acharya, Rebecca Reis, Meta Volcic, GuanQun Liu, May K Wang , Bing Shao Chia, Rayhane Nchioua, Rüdiger Groß, Jan Münch, Frank Kirchhoff, Konstantin M J Sparrer, Michaela U Gack
Actin cytoskeleton remodeling primes RIG-I-like receptor activation
Cell. 2022, 185(19):3588-3602, PMID:36113429
1月19日:福澤
Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, Ernst RK. 2022.
A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species.
Microbiol Spectr 10:e01445-21.
1月12日: 上村
Rémi Le Guern , Teddy Grandjean , Sarah Stabler, Marvin Bauduin, Philippe Gosset , Éric Kipnis & Rodrigue Dessein
Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomo- nas aeruginosa lung infection
Nature communications volume14, Article number: 78 (2023)
1月5日:横田
Wilson A, Fegan N, Turner MS.
Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications.
Int J Food Microbiol. 2022; 381:109905. doi: 10.1016/j.ijfoodmicro.2022.109905. PMID: 36095868
<2022年>
12月22日:中村
Anversa L, et al.,
Quality of dialysis water and dialysate in haemodialysis centres: Highlight for occurrence of non-fermenting gram-negative bacilli
J Appl Microbiol. 2022 132 (4):3416-3429 PMID: 35108426
12月15日: 永島
Yoshiyuki Mishima et al.,
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells
J Clin Invest. 2019, 129(9): 3702–3716.
doi: 10.1172/JCI93820 PMCID: PMC6715367 PMID: 31211700
12月8日:小笠原
Slim Fourati et.al.,
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
nature immunology. 2022 Oct 31.doi: 10.1038/s41590-022-01329-5. PMID:36316476
12月1日:白石
Kevin Champagne-Jorgensen, Tamina A Jose, Andrew M Stanisz, M Firoz Mian, Alexander P Hynes, John Bienenstock.
Bacterial membrane vesicles and phages in blood after consumption of lacticaseibacillus rhamnosus JB-1.
Gut Microbes. 2021 Jan-Dec;13(1):1993583.
PMID: 34747333. DOI: 10.1080/19490976.2021.1993583.
11月24日:吉田
Joanne Haney, Swetha Vijayakrishnan, James Streetley, Kieran Dee, Daniel Max Goldfarb, Mairi Clarke, Margaret Mullin, Stephen D Carter, David Bhella, Pablo R Murcia
Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles.
Nat Microbiol. 2022. doi: 10.1038/s41564-022-01242-5. PMID: 36280786.
11月17日:上村
Amandine Nucci, Eduardo P C Rocha, Olaya Rendueles
Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits
Nat Commun. 2022 Aug 13;13(1):4751. doi: 10.1038/s41467-022-32504-9. PMID: 35963864.
11月10日:山本
Joseph D Trimarco, Sarah L Nelson, Ryan R Chaparian, Alexandra I Wells, Nathan B Murray, Parastoo Azadi, Carolyn B Coyne, Nicholas S Heaton
Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection
Nat Commun. 2022 Oct 29;13(1):6456. doi: 10.1038/s41467-022-34111-0.
10月20日:谷向
Krist Helen Antunes et al.
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.
Nat Commun . 2019 Jul 22;10(1):3273.
PMID: 31332169 DOI: 10.1038/s41467-019-11152-6
10月13日:横田
Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H.
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
Sci Adv. 2022; 8(9):eabj9867. doi: 10.1126/sciadv.abj9867. PMID: 35245125
9月29日:中村
Eiichi Osono, Kazumi Honda, Yuki Inoue, Kyouko Ichimura, Chisako Kamano, Toshio Akimoto, Shinya Kawamoto, Yoshihiko Norose, Shun Takaku , Rimpei Morita
Sodium Hypochlorite is Effective against Biofilms in Dialysis Equipment
Biocontrol Sci, 2021, PMID: 33716244 DOI: 10.4265/bio.26.1
9月22日: 福澤
Liao W, Cui Y, Quan J, Zhao D, Han X, Shi Q, Wang Q, Jiang Y, Du X, Li X, Yu Y. 2022.
High prevalence of colistin resistance and mcr-9/10 genes in Enterobacter spp. in a tertiary hospital over a decade.
Int J Antimicrob Agents 59(5):106573.
PMID: 35307563 DOI: 10.1016/j.ijantimicag.2022.106573
9月15日:小笠原
Nenad Bartonicek, Romain Rouet, Joanna Warren, Claudia Loetsch, Gabriela Santos Rodriguez, Stacey Walters, Francis Lin, David Zahra, James Blackburn, Jillian M Hammond, Andre L M Reis, Ira W Deveson, Nathan Zammit, Mahdi Zeraati, Shane Grey, Daniel Christ, John S Mattick, Tatyana Chtanova, Robert Brink, Marcel E Dinger, Robert J Weatheritt, Jonathan Sprent, Cecile King
The retroelement Lx9 puts a brake on the immune response to virus infection
Nature. 2022 Aug;608(7924):757-765.
PMID: 35948641 DOI: 10.1038/s41586-022-05054-9
9月8日:白石
Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu, Sung-Moo Park, Betsabeh Khoramian Tusi, Xiangjun Chen, Jaeyoung Kwon, Pavel Filipčík, Andrew S. Bolze, Zehua Liu, Hera Vlamakis, Daniel B. Graham, Sara J. Buhrlage, Ramnik J. Xavier & Jon Clardy
Akkermansia muciniphila phospholipid induces homeostatic immune responses
Nature. 2022 Aug;608(7921):168-173.
PMID: 35896748 DOI: 10.1038/s41586-022-04985-7
9月1日:谷向
Julien Sourimant , Carolin M Lieber , Jeong-Joong Yoon , Mart Toots , Mugunthan Govindarajan , Venkata Udumula , Kaori Sakamoto , Michael G Natchus , Joseph Patti , John Vernachio , Richard K Plemper
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase
Science Advances. 2022 Jun 24; 8(25):eabo2236
PMID: 35749502 PMCID: PMC9232112 DOI: 10.1126/sciadv.abo2236
8月18日:吉田
Dong Gu, Xinghai Yu, Dan Wang, Zhifei Li, Yu Zhou, Guodong Xu, Bing Yuan, Yali Qin, Mingzhou Chen
Exploring key genes and mechanisms in respiratory syncytial virus-infected BALB/c mice via multi-organ expression profiles
Front Cell Infect Microbiol. 2022 May 2;12:858305. PMID: 35586251.
8月4日:山本
S Ghosh , M Kumar , M Santiana , A Mishra , M Zhang , H Labayo, A M Chibly, H Nakamura, T Tanaka, W Henderson, E Lewis, O Voss, Y Su, Y Belkaid, J A Chiorini, M P Hoffman, N Altan-Bonnet
Enteric viruses replicate in salivary glands and infect through saliva
Nature. 2022 Jul;607(7918):345-350.
doi: 10.1038/s41586-022-04895-8. Epub 2022 Jun 29.
7月28日:永島
Marije Oosting, Shih-Chin Cheng, Judith M Bolscher, Rachel Vestering-Stenger , Theo S Plantinga , Ineke C Verschueren, Peer Arts, Anja Garritsen, Hans van Eenennaam, Patrick Sturm, Bart-Jan Kullberg , Alexander Hoischen , Gosse J Adema , Jos W M van der Meer , Mihai G Netea , Leo A B Joosten
Human TLR10 is an anti-inflammatory pattern-recognition recep
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4478-84.
doi: 10.1073/pnas.1410293111.Epub 2014 Oct 6.
7月7日:上村
Claire L. Gorrie , Mirjana Mirčeta, Ryan R. Wick , Louise M. Judd, Margaret M. C. Lam, Ryota Gomi Iain J. Abbott, Nicholas R. Thomson , Richard A. Strugnell , Nigel F. Pratt, Jill S. Garlick, Kerrie M. Watson, Peter C. Hunter, David V. Pilcher, Steve A. McGloughlin, Denis W. Spelman, Kelly L. Wyres , Adam W. J. Jenney & Kathryn E. Holt
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen
Nature Communications (2022)13:3017 | https://doi.org/10.1038/s41467-022-30717-6
6月30日:横田
Deng H, Zhang M, Yi C, Ge L
CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.
Cell. 2022 Apr 14;185(8):1325-1345.e22. doi: 10.1016/j.cell.2022.03.005. PMID: 35366418
6月9日:福澤
Gallardo A, Iglesias M-R, Ugarte-Ruiz M, Hernández M, Miguela-Villoldo P, Gutiérrez G, Rodríguez-Lázaro D, Domínguez L, Quesada A
The plasmid-mediated Kluyvera-like arnBCADTEF operon confers colistin (hetero)resistance to Escherichia coli.
Antimicrob Agents Chemother. 2021 Mar8;65(5):e00091-21. doi: 10.1128/AAC.00091-21. PMID: 33685891
5月26日:白石
Hao H, Zhang X, Tong L, Liu Q, Liang X, Bu Y, Gong P, Liu T, Zhang L, Xia Y, Ai L, Yi H
Effect of extracellular vesicles derived from Lactobacillus plantarum Q7 on gut microbiota and ulcerative colitis in mice.
Front Immunol. 2021 Dec 2;12:777147. doi: 10.3389/fimmu.2021.777147. PMID: 34925349
5月19日:中村
Hiroshi Nozaki, Yoshihiro Tange, Yoji Inada, Takashi Uchino, Nakanobu Azuma
Leakage of Endotoxins through the Endotoxin Retentive Filter: An in vitro Study
Blood Purif. 2022 Jan 12;1-9.
PMID: 35021168 DOI: 10.1159/000520792
5月12日：谷向
Tomer Zohar, Jeff C Hsiao, Nickita Mehta, Jishnu Das, Anush Devadhasan, Wiktor Karpinski, Cheryl Callahan, Michael P Citron, Daniel J DiStefano, Sinoeun Touch, Zhiyun Wen, Jeffrey R Sachs, Pedro J Cejas, Amy S Espeseth, Douglas A Lauffenburger, Andrew J Bett, Galit Alter
Cell Host Microbe. 2022 Jan 12;30(1):41-52.e5.
Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates
PMID: 34879230 DOI: 10.1016/j.chom.2021.11.006
4月28日：小笠原
Ji Eun Oh, Eric Song, Miyu Moriyama, Patrick Wong, Sophia Zhang, Ruoyi Jiang, Shirin Strohmeier, Steven H Kleinstein, Florian Krammer, Akiko Iwasaki
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Sci Immunol, 2021 6(66):eabj5129.
PMID: 34890255 PMCID: PMC8762609
4月21日：山本
Dong Gu, Xinghai Yu, Dan Wang, Zhifei Li, Yu Zhou, Guodong Xu, Bing Yuan, Yali Qin, Mingzhou Chen
SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection
J Virol, 2022 Apr, PMID: 35420441
4月7日：上村
Ruggero La Rosa, Elio Rossi, Adam M. Feist, Helle Krogh Johansen & Søren Molin
Compensatory evolution of Pseudomonas aeruginosa’s slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
Nature Communications volume 12, Article number: 3186 (2021)
doi.org/10.1038/s41467-021-23451-y
3月24日：横田
Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ.
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory.
iScience. 2021;24(12):103479. doi: 10.1016/j.isci.2021.103479. PMID: 34841223.
3月17日：福澤
Ghirga F, Stefanelli R, Cavinato L, Lo Sciuto A, Corradi S, Quaglio D, Calcaterra A, Casciaro B, Loffredo MR, Cappiello F, Morelli P, Antonelli A, Rossolini GM, Mangoni M, Mancone C, Botta B, Mori M, Ascenzioni F, Imperi F. 2020. A novel colistin adjuvant identified by virtual screening for ArnT inhibitors.
J Antimicrob Chemother 75:2564–2572.
3月10日：谷向
Miaoge Xue, et al.,
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus
PLoS Pathog, 2021, 17(12)e1010142
PMID: 34929018 PMCID: PMC8759664 DOI: 10.1371/journal.ppat.1010142
3月3日：白石
Dongwook Lee, Jintaek Im, Dong Hyun Park, Sungho Jeong, Miri Park, Seokmin Yoon, Jaewoong Park and Seung Hyun Han.
Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory Effects on the Biofilm Formation of Dental Pathogenic Bacteria.
Front Microbiol. 12:758161. (2021)
2月24日：永島
Qin Liu, et al.,
Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Gut, 2022, 71(3):544-552
PMID: 35082169 PMCID: PMC8814432 DOI: 10.1136/gutjnl-2021-325989
2月3日：中村
Juan-Pablo Cuevas et al.,
Characterization of the Bacterial Biofilm Communities Present in Reverse-Osmosis Water Systems for Haemodialysis
Microorganisms, 2020 Sep 15;8(9):1418
PMID: 32942620 PMCID: PMC7564833 DOI: 10.3390/microorganisms8091418
1月27日：上村
Dennis J. Doorduijn et al.,
Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.
PLOS Pathog.2021 Nov 9;17(11) PMID: 34752492 PMCID: PMC8604303 DOI: 10.1371/journal.ppat.101005
1月20日：小笠原
Elizabeth J Fay, et al.,
Natural rodent model of viral transmission reveals biological features of virus population dynamics
J Exp Med, 2022
PMID: 34958350 DOI: 10.1084/jem.20211220
1月13日：山本
Sandra Axberg Pålsson, et al.,
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Frontiers in Immunology, 2020
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<2021年>
12月16日：白石
Won-Sik Yeo, Bohyun Jeong, Nimat Ullah, Majid Ali Shah, Amjad Ali, Kyeong Kyu Kim and Taeok Bae.
Ftsh Sensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics by Degrading YpfP, a Lipoteichoic Acid Synthesis Enzyme. Antibiotics (Basel). 10(10):1198. (2021)
12月9日：谷向
Georgia Deliyannis et al.,
TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs
JCI Insight. 2021 Mar 8;6(5):e140267.doi: 10.1172/jci.insight.140267. PMID: 33561017
12月2日：横田
Jiang X, Yang K, Yuan B, Han M, Zhu Y, Roberts KD, Patil NA, Li J, Gong B, Hancock REW, Velkov T, Schreiber F, Wang L, Li J.
Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii.
J Antimicrob Chemother. 2020 Dec 1;75(12):3534-3543. doi: 10.1093/jac/dkaa376. PMID: 32911540
11月18日：小笠原
Ryan A Flynn, Kayvon Pedram , Stacy A Malaker, Pedro J Batista , Benjamin A H Smith, Alex G Johnson, Benson M George, Karim Majzoub , Peter W Villalta, Jan E Carette, Carolyn R Bertozzi
Small RNAs are modified with N-glycans and displayed on the surface of living cells
Cell.2021 Jun 10;184(12):3109-3124.e22.doi: 10.1016/j.cell.2021.04.023. PMID: 34004145
11月11日：山本
Monika Bajorek, Marie Galloux, Charles-Adrien Richard, Or Szekely, Rina Rosenzweig, Christina Sizun, Jean-Francois Eleouet
Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein
J Virol. 2021 Jan 6;95(7):e02217-20.doi: 10.1128/JVI.02217-20 PMID: 33408180
11月4日：福澤
Wand, M. E. & Mark Sutton, J. Mutations in the two component regulator systems PmrAB and PhoPQ give rise to increased colistin resistance in Citrobacter and Enterobacter spp. J. Med. Microbiol. 69, 521–529 (2020).10.1099/jmm.0.001173
10月28日：白石
Kevin Champagne-Jorgensen, M Firoz Mian, Karen-Anne McVey Neufeld, Andrew M Stanisz, John Bienenstock.
Membrane vesicles of Lacticaseibacillus rhamnosus JB-1 contain immunomodulatory lipoteichoic acid and are endocytosed by intestinal epithelial cells. Sci Rep. 11 (1) : 13756.(2021)
10月21日：永島
Fernando F Anhê, Nicole G Barra, Joseph F Cavallari, Brandyn D Henriksbo, Jonathan D SchertzerMetabolic endotoxemia is dictated by the type of lipopolysaccharide
Cell Rep. 2021 Sep 14;36(11):109691.
PMID: 34525353 DOI: 10.1016/j.celrep.2021.109691
10月14日：横田
Eichner H, Karlsson J, Spelmink L, Pathak A, Sham L-T, Henriques-Normark B, Loh E.
RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion
PLoS Pathog. 2021 Apr 29;17(4):e1009513. doi: 10.1371/journal.ppat.1009513.
10月7日:上村
Francesca L Short et al.
Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae
Infect Immun. 2020 Jul 21;88(8):e00043-20.doi: 10.1128/IAI.00043-20. Print 2020 Jul 21
9月16日: 谷向
Min Zheng et al.,
TLR2 senses the SARS-CoV-2 envelope protein to
produce inflammatory cytokines
Nat Immunol 2021 Jul;22(7):829-838.
doi: 10.1038/s41590-021-00937-x. Epub 2021 May 7.
9月9日:山本
Lempp, F.A., Soriaga, L., Montiel-Ruiz, M. et al.
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies
Nature Inpress, https://doi.org/10.1038/s41586-021-03925-1
9月2日:小笠原
Jennifer Risso-Ballester, Marie Galloux, Jingjing Cao, et al.,
A condensate-hardening drug blocks RSV replication in vivo,
Nature 595, 596-599, 2021, PMID: 34234347
8月26日:永島
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
Meagan P O'Brien , Eduardo Forleo-Neto, Bret J Musser, et al.,
N Engl J Med. 2021 Aug 4.doi: 10.1056/NEJMoa2109682. PMID: 34347950
8月19日:白石
Sassine J, Sousa J, Lalk M, Daniel RA, Vollmer W.
Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis.
Sci Rep. 10 (1) : 17910. (2020)
8月5日: 上村
Kasturi Banerjee,Michael P. Motley,Elizabeth Diago-Navarro, Bettina C. Fries
”Serum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected Patients”
mSphere. 2021 Mar 3;6(2):e01335-20. doi: 10.1128/mSphere.01335-20. PMID: 33658281
7月29日:中村
Lili Chan , Kumardeep Chaudhary , Aparna Saha, et al.,
AKI in Hospitalized Patients with COVID-19
J Am Soc Nephrol. 2021 Jan;32(1):151-160. PMID: 32883700 PMCID: PMC7894657
7月8日:谷向
Li Wang , Qihui Zhu, Kunlun Xiang, Yaling Zhang, Baocun Li , Xin Yu, Guang Yang , Chungen Liang ,
Hongying Yun , Meifang Zhang , Ning Qin , Lu Gao
Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor
AAC, 2021, PMID: 33782012 DOI: 10.1128/AAC.02576-20
6月10日:横田
Sang-Sang Park, Norberto Gonzalez-Juarbe, Eriel Martínez, Joanetha Yvette Hale, Yi-Han Lin, Joshua T Huffines, Katherine L Kruckow, David E Briles, Carlos J Orihuela
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence
mBio. 2021 May 4;12(3):e00673-21. doi: 10.1128/mBio.00673-21. PMID: 33947761
6月3日:小笠原
Zharko Daniloski, Tristan X Jordan , Hans-Hermann Wessels, Daisy A Hoagland, Silva Kasela, Mateusz Legut, Silas Maniatis , Eleni P Mimitou, Lu Lu, Evan Geller, Oded Danziger , Brad R Rosenberg, Hemali Phatnani, Peter Smibert, Tuuli Lappalainen, Benjamin R tenOever, Neville E Sanjana
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
Cell. 2021 Jan 7;184(1):92-105.e16. PMID: 33147445
5月27日:福澤
Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z.
Identification of novel mobile colistin resistance gene mcr-10.
Emerg Microbes Infect, 2020 9:508–516. PMID: 32116151
5月20日:佐藤
Jamie L Dombach, Joaquin L J Quintana, Toni A Nagy, Chun Wan, Amy L Crooks, Haijia Yu, Chih-Chia Su, Edward W Yu, Jingshi Shen, Corrella S Detweiler. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog. 2020 Dec 8;16(12):e1009119. PMID: 33290418
4月22日:永島
1) Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination,
Andreas Greinacher, Thomas Thiele, Theodore E Warkentin, Karin Weisser, Paul A Kyrle, Sabine Eichinger
N Engl J Med, 2021 PMID: 33835769
2) Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
Schultz NH, et al. N Engl J Med. 2021. PMID: 33835768
4月15日:中村
Michael Hulko, Verena Dietrich, Ilona Koch, Alexander Gekeler, Michael
Gebert, Werner Beck, Bernd KrausePyrogen retention: Comparison of the novel medium cut-off (MCO)
membrane with other dialyser membranes
Sci Rep 2019 May 1;9(1):6791.
PMID: 31043670
PMID: 31043670
4月8日:上村
Imane El Meouche and Mary J Dunlop
Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation
Science. 2018 Nov 9; 362(6415): 686–690.
PMCID: PMC6343669
4月1日:山本
Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B.
Sorting nexin 5 mediates virus-induced autophagy and immunity.
Nature, 2021 PMID: 33328639
3月25日:白石
Anthony R. Hesser, Kaitlin Schaefer, Wonsik Lee, and Suzanne Walker.
Lipoteichoic acid polymer length is determined by competition between free starter units.
Proc Natl Acad Sci USA. 117 (47) : 29669-29676. (2020)
3月18日:横田 「alpha-Gal syndrome」
Crispell G, Commins SP, Archer-Hartman SA, Choudhary S, Dharmarajan G, Azadi P, Karim S.
Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy.
Front Immunol. 2019 May 17;10:1056. doi: 10.3389/fimmu.2019.01056.
3月11日:小笠原
Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ; Yale IMPACT Research Team, Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A.
Sex differences in immune responses that underlie COVID-19 disease outcome.Nature. 2020 Dec;588(7837):315-320.PMID: 32846427
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A; Yale IMPACT Team, Herbst R, Shaw AC, Medzhitov R, Schulz WL, Grubaugh ND, Dela Cruz C, Farhadian S, Ko AI, Omer SB, Iwasaki A.
Longitudinal analyses reveal immunological misfiring in severe COVID-19.Nature. 2020 Aug;584(7821):463-469.PMID: 32717743
3月4日:佐藤
James K Martin, Joseph P Sheehan, Benjamin P Bratton, Gabriel M Moore, André Mateus, Sophia Hsin-Jung Li, Hahn Kim, Joshua D Rabinowitz, Athanasios Typas, Mikhail M Savitski, Maxwell Z Wilson, Zemer Gitai
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance
Cell. 2020 Jun 25;181(7):1518-1532.e14. doi: 10.1016/j.cell.2020.05.005. Epub 2020 Jun 3. PMID: 32497502
2月25日:中村
Xishao Xie, Junni Wang, Shilong Xiang, Zhimin Chen, Xiaohui Zhang, Jianghua Chen
Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis.
BMC Nephrol, 2019, 20(1):128, PMID 30975091
2月4日:永島
Yun Kit Yeoh et al., Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.
Gut, 2021, PMID: 33431578
1月21 日: 福澤
Beyrouthy R, Barets M, Marion E, Dananché C, Dauwalder O, Robin F, Gauthier L, Jousse A, Dortet L, Guérin F, Bénet T, Cassier P, Vanhems P, Bonnet R. 2018. Novel Enterobacter lineage as leading cause of nosocomial outbreak involving carbapenemase-producing strains.
Emerg Infect Dis 24:1505–1515.doi: 10.3201/eid2408.180151
1月14日: 上村
Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker
Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection
mBio, 2019 Sep 17;10(5):e01822-19. doi: 10.1128/mBio.01822-19.
<2020年>
12月17日: 山本
Ghosh S. et al
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
Cell, 2020 Dec 10;183(6):1520-1535.e14., doi: 10.1016/j.cell.2020.10.039. Epub 2020 Oct 27.
12月10日：白石
Kyong-Su Park, Jaewook Lee, Changjin Lee, Hyun Taek Park, Jung-Wook Kim, Oh Youn Kim, Sae Rom Kim, Madeleine Rådinge, Hoe-Yune Jung, Jaesung Park, Jan Lötvall, and Yong Song Gho
Sepsis-like systemic inflammation induced by nano-sized extracellular vesicles from feces
Front Microbioi. 9:1735 (2018)
12月3日: 横田
Bradshaw JL, Pipkins HR, Keller LE, Pendarvis JK, McDaniel LS.
Mucosal Infections and Invasive Potential of Nonencapsulated Streptococcus pneumoniae Are Enhanced by Oligopeptide Binding Proteins AliC and AliD.
mBio. 2018 Jan 16;9(1):e02097-17. doi: 10.1128/mBio.02097-17. PMID: 29339428
10月29日:福澤
Shazad Mushtaq, Rosy Reynolds, Michael C Gilmore, Olubukola Esho, Rachael Adkin, Inmaculada García-Romero, Aiysha Chaudhry, Carolyne Horner, Toby L Bartholomew, Miguel A Valvano, Magdalena Dry, John Murray, Bruno Pichon, David M Livermore
Inherent colistin resistance in genogroups of the Enterobacter cloacae complex: epidemiological, genetic and biochemical analysis from the BSAC Resistance Surveillance Programme
J Antimicrob Chemother, 2020 Sep 1;75(9):2452-2461.
10月22日:小笠原
Habibi MS, Thwaites RS, Chang M, Jozwik A, Paras A, Kirsebom F, Varese A, Owen A, Cuthbertson L, James P, Tunstall T, Nickle D, Hansel TT, Moffatt MF, Johansson C, Chiu C, Openshaw PJM.
Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.
Science. 2020 Oct 9;370(6513):eaba9301. doi: 10.1126/science.aba9301. PMID: 33033192
10月15日: 上村
Michelle K. Paczosa,Rebecca J. Silver, Anne L. McCabe,Albert K. Tai,Colin H. McLeish,David W. Lazinski,Joan MecsasTransposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice
Infect Immun. 2020 Apr; 88(4): e00034-20. doi: 10.1128/IAI.00034-20.PMID: 31988174
10月8日:佐藤
Ákos Nyerges, Bálint Csörgő , Gábor Draskovits, Bálint Kintses, Petra Szili, Györgyi Ferenc, Tamás Révész, Eszter Ari, István Nagy , Balázs Bálint , Bálint Márk Vásárhelyi , Péter Bihari , Mónika Számel, Dávid Balogh, Henrietta Papp, Dorottya Kalapis, Balázs Papp, Csaba Pál Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. doi: 10.1073/pnas.1801646115.Epub 2018 Jun 5.PMID: 29871954
10月1日:中村
Maurizio Bossola, Maurizio Sanguinetti, Donata Scribano, Cecilia Zuppi, Stefania Giungi, Giovanna Luciani, Riccardo Torelli, Brunella Posteraro, Giovanni Fadda, Luigi Tazza
Circulating bacterial-derived DNA fragments and markers of inflammation in chronic hemodialysis patients
Clin J Am Soc Nephrol 2009 4(2):379-85.
9月24日: 福澤
Joseph D. Lutgring,Anny Kim,Davina Campbell,Maria Karlsson,Allison C. Brown,Eileen M. Burd.
Evaluation of the MicroScan Colistin Well and Gradient Diffusion Strips for Colistin Susceptibility Testing in Enterobacteriaceae. Journal of Clinical Microbiology 2019 57:e01866-18.
9月17日:山本
Griffiths CD, Bilawchuk LM, McDonough JE, Jamieson KC, Elawar F, Cen Y, Duan W, Lin C, Song H, Casanova JL, Ogg S, Jensen LD, Thienpont B, Kumar A, Hobman TC, Proud D, Moraes TJ, Marchant DJ.
IGF1R is an entry receptor for respiratory syncytial virus
Nature. 2020 Jul;583(7817):615-619. doi: 10.1038/s41586-020-2369-7. Epub 2020 Jun 3. PMID: 32494007
9月10日：白石
C. K. Stein-Thoeringer, K. B. Nichols, A. Lazrak, M. D. Docampo, A. E. Slingerland, J. B. Slingerland, A. G. Clurman, G. Armijo, A. L. C. Gomes, Y. Shono, A. Staffas, M. Burgos da Silva, S. M. Devlin, K. A. Markey, D. Bajic, R. Pinedo, A. Tsakmaklis, E. R. Littmann, A. Pastore, Y. Taur, S. Monette, M. E. Arcila, A. J. Pickard, M. Maloy, R. J. Wright, L. A. Amoretti, E. Fontana, D. Pham, M. A. Jamal, D. Weber, A. D. Sung, D. Hashimoto, C. Scheid, J. B. Xavier, J. A. Messina, K. Romero, M. Lew, A. Bush, L. Bohannon, K. Hayasaka, Y. Hasegawa, M. J. G. T. Vehreschild, J. R. Cross, D. M. Ponce, M. A. Perales, S. A. Giralt, R. R. Jenq, T. Teshima, E. Holler, N. J. Chao, E. G. Pamer, J. U. Peled, M. R. M. van den Brink
Lactose drives Enterococcus expansion to promote graft-versus-host disease.
Science. 366:1143-1149 (2019)
9月3日：上村
A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity
Kimberly A. Walker,corresponding authora Taryn A. Miner,a Michelle Palacios, Dominika Trzilova, Daniel R. Frederick, Christopher A. Broberg, Victoria E. Sepúlveda, Joshua D. Quinn, and Virginia L. Millera
mBio. 2019 Mar-Apr; 10(2): e00089-19. doi: 10.1128/mBio.00089-19 PMID: 30914502
8月27日：福澤
MgrB Inactivation Is Responsible for Acquired Resistance to Colistin in Enterobacter hormaechei subsp. steigerwaltii.
Amel Mhaya, Dominique Bégu,Slim Tounsi,Corinne Arpin.
Antimicrobial Agents and Chemotherapy PMID: 32253218 PMCID: PMC7269514 DOI: 10.1128/AAC.00128-20
8月6日：小笠原
p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.
Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.
J Clin Invest. 2019 Nov 1;129(11):4875-4884. doi: 10.1172/JCI128626. PMID: 31430261
7月22日：佐藤
Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae
Christoph M Ernst, Julian R Braxton, Carlos A Rodriguez-Osorio, Anna P Zagieboylo, Li Li, Alejandro Pironti , Abigail L Manson , Anil V Nair , Maura Benson, Kaelyn Cummins, Anne E Clatworthy, Ashlee M Earl, Lisa A Cosimi, Deborah T Hung
Nat Med. 2020 May;26(5):705-711. doi: 10.1038/s41591-020-0825-4. PMID: 32284589
7月15日：福澤
Colistin Heteroresistance in Enterobacter Cloacae Is Regulated by PhoPQ-dependent 4-amino-4-deoxy-l-arabinose Addition to Lipid A
Katie N Kang, Dustin R Klein, Misha I Kazi, François Guérin, Vincent Cattoir, Jennifer S Brodbelt, Joseph M Boll
Mol Microbiol., 2019, PMID: 30873646
7月1日：福澤 自粛期間中の課題の論文
Unstable Tandem Gene Amplification Generates Heteroresistance (Variation in Resistance Within a Population) to Colistin in Salmonella Enterica,
Karin Hjort, Hervé Nicoloff, Dan I Andersson
Mol Microbiol., 2016, PMID: 27381382
7月1日：横田
The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity.
Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S.
J Bacteriol. 2020. doi: 10.1128/JB.00149-20. PMID: 32482719
4月9日：山本
新型コロナの論文紹介です。以下の論文に加えて、阻害薬の開発状況などまとめてみます
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S.
Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052.
4月2日：福澤
Mechanisms and clinical relevanceof bacterial heteroresistance
Andersson DI, Nicoloff H, Hjort K.
Nat Rev Microbiol. 2019 Aug;17(8):479-496. doi: 10.1038/s41579-019-0218-1. Epub 2019 Jun 24. Review.
3月26日：志賀
Staphylococcus aureus induces IL-8 expression through its lipoproteins in the human intestinal epithelial cell, Caco-2.
Kang SS, Noh SY, Park OJ, Yun CH, Han SH.
Cytokine. 2015 Sep;75(1):174-80. doi: 10.1016/j.cyto.2015.04.017. PMID: 25982554
3月12日：小笠原
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori MA, Tangy F, Stavru F, Bessonov S, Dessen A, Muchardt C, Lebreton A, Komarova AV, Cossart P.
Cell Host Microbe. 2019 26(6):823-835. PMID: 31761719; PubMed Central PMCID: PMC6907008.
2月27日：佐藤
Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale G, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.
Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. PMID: 31645764
1月29日：永島
Weak Agonistic LPS Restores Intestinal Immune Homeostasis.
Steimle A, Michaelis L, Di Lorenzo F, Kliem T, Münzner T, Maerz JK, Schäfer A, Lange A, Parusel R, Gronbach K, Fuchs K, Silipo A, Öz HH, Pichler BJ, Autenrieth IB, Molinaro A, Frick JS
Mol Ther. 2019 Nov 6;27(11):1974-1991. PMID:31416777. doi: 10.1016/j.ymthe.2019.07.007. Epub 2019 Jul 19.
1月16日：志賀
Lipoteichoic Acid From Lactobacillus Plantarum Inhibits Pam2CSK4-induced IL-8 Production in Human Intestinal Epithelial Cells
Noh SY, Kang S-S, Yun C-H, Han SH
Mol Immunol, 64 (1), 183-9 Mar 2015PMID: 25481370 DOI: 10.1016/j.molimm.2014.11.014
1月9日: 横田
Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages
Kawano M, Miyoshi M, Miyazaki T
Front Immunol, 10, 845 2019 Apr 17 eCollection 2019 PMID: 31057558 PMCID: PMC6478895 DOI: 10.3389/fimmu.2019.00845
<2019年>
12月19日: 福澤
Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane protein.
Huang L, Feng Y, Zong Z. J Antimicrob Chemother. 2019 Sep 1;74(9):2551-2558. doi: 10.1093/jac/dkz236.
12月12日：山本
Enterovirus pathogenesis requires the host methyltransferase SETD3.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE.
Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.
11月28日: 白石
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.
Shao Y, Forster SC1, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.
Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.
11月21日: 桧山
Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.
Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.
Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.PMID: 30814593
10月10日: 小笠原
Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.
Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.
Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24.PMID: 31235953
10月3日: 佐藤
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.PMID: 28614296
9月26日: 福澤
The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.
Nicoloff H, Hjort K, Levin BR, Andersson DI. Nat Microbiol. 2019 Mar;4(3):504-514. doi: 10.1038/s41564-018-0342-0. Epub 2019 Feb 11.
PMID: 30742072
9月19日: 横田
Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients. Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR. Sci Rep. 2019 Jul 22;9(1):10588. doi: 10.1038/s41598-019-46745-0. PMID: 31332258
9月12日: 桧山
Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.
Ibana JA, Sherchand SP, Fontanilla FL, Nagamatsu T, Schust DJ, Quayle AJ, Aiyar A. Sci Rep. 2018 May 31;8(1):8476. doi: 10.1038/s41598-018-26765-y. PMID: 29855501
8月22日: 山本
NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11.PMID: 30982665
8月8日: 永島
Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis.Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF. Sci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038/s41598-018-32366-6.
7月25日: 白石
Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.
Taheri N, Mahmud AKMF, Sandblad L, Fällman M, Wai SN, Fahlgren A. Sci Rep. 2018 Nov 19;8(1):16996. doi: 10.1038/s41598-018-35409-0.
PMID:30451931
7月18日: 志賀
Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Takagi A, Yanagi H, Ozawa H, Uemura N, Nakajima S, Inoue K, Kawai T, Ohtsu T, Koga Y. Gastroenterol Res Pract. 2016;2016:7490452. doi: 10.1155/2016/7490452. Epub 2016 Jul 11.PMID: 27478434
6月26日: 福澤
Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae.
Band VI, Crispell EK, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS.
Nat Microbiol. 2016 May 9;1(6):16053. doi: 10.1038/nmicrobiol.2016.53.PMID: 27572838
6月19日: 小笠原
Airway response to respiratory syncytial virus has incidental antibacterial effects.
Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Nat Commun. 2019 May 17;10(1):2218. doi: 10.1038/s41467-019-10222-z. PMID: 31101811
5月29日: 永島
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Cario E, Gerken G, Podolsky DK. Gastroenterology. 2007 Apr;132(4):1359-74. Epub 2007 Feb 25. DOI:10.1053/j.gastro.2007.02.056. PMID:17408640
5月23日: 佐藤
Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131. Sarkar S, Hutton ML, Vagenas D, Ruter R, Schüller S, Lyras D, Schembri MA, Totsika M. J Infect Dis. 2018 Aug 14;218(6):979-990. doi: 10.1093/infdis/jiy031. PMID:29471349
5月16日: 桧山
Fur Represses Adhesion to, Invasion of, and Intracellular Bacterial Community Formation within Bladder Epithelial Cells and Motility in Uropathogenic Escherichia coli. Kurabayashi K, Agata T, Asano H, Tomita H, Hirakawa H.Infect Immun. 2016 Oct 17;84(11):3220-3231. doi: 10.1128/IAI.00369-16. Print 2016 Nov. PMID:27572332
4月18日: 山本
Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT.Cell Rep. 2018 Mar 20;22(12):3304-3314. doi:10.1016/j.celrep.2018.03.003.
4月11日：志賀
Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice.
Ohsawa K, Uchida N, Ohki K, Yokogoshi H. Int J Food Sci Nutr. 2018 Feb;69(1):33-45.
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3月28日：福澤
Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex. Guérin F, Isnard C, Cattoir V, Giard JC. Antimicrob Agents Chemother. 2015 Dec;59(12):7753-61. doi: 10.1128/AAC.01729-15. Epub 2015 Oct 5.PMID: 26438498
2月28日：永島
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. PMID:30675064
2月6日：横田
Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671. doi: 10.1073/pnas.1809100115.
PMID: 30352847
<2018年>
12月20日:小笠原
Tropism for tuft cells determines immune promotion of norovirus pathogenesis.
Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.
Science. 2018 Apr 13;360(6385):204-208.
PMID: 29650672
12月6日:佐藤
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.
Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C.
Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.
PMID: 29795541
11月15日：永島
Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.
Kamdar K, Johnson AMF, Chac D, Myers K, Kulur V, Truevillian K, DePaolo RW.
J Immunol. 2018 Jul 1;201(1):230-242. doi: 10.4049/jimmunol.1701216. Epub 2018 May 23.
PMID: 29794015
11月8日：山本
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.
Ding B, Zhang L, Li Z, Zhong Y, Tang Q, Qin Y, Chen M.
Cell Host Microbe. 2017 Apr 12;21(4):538-547.e4. doi: 10.1016/j.chom.2017.03.004.
PMID: 28407488
10月18日：横田
Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.
Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T.
PLoS Pathog. 2018 Apr 5;14(4):e1006955. doi: 10.1371/journal.ppat.1006955. eCollection 2018 Apr.
PMID: 29621339
10月11日: 桧山
Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent UrinaryTract Infection.
Ali ASM, Mowbray C, Lanz M, Stanton A, Bowen S, Varley CL, Hilton P, Brown K, Robson W, Southgate J, Aldridge PD, Tyson-Capper A, Abraham S, Pickard RS, Hall J.
Sci Rep. 2017 Sep 8;7(1):11039. doi: 10.1038/s41598-017-10445-4.
PMID: 28887442
9月27日: 白石
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW
Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. Erratum in: Nature. 2018 Aug 29
PMID: 30089902
9月20日: 山本
Optimized arylomycins are a new class of Gram-negative antibiotics.
Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.
Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.
PMID: 30209367
9月6日: 佐藤
Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.
Shaik S, Ranjan A, Tiwari SK, Hussain A, Nandanwar N, Kumar N, Jadhav S, Semmler T, Baddam R, Islam MA, Alam M, Wieler LH, Watanabe H, Ahmed N
MBio. 2017 Oct 24;8(5). pii: e01596-17. doi: 10.1128/mBio.01596-17.
PMID: 29066550
8月30日: 本田
Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.
Sela U, Euler CW, Correa da Rosa J, Fischetti VA.
PLoS Pathog. 2018 Jan 11;14(1):e1006726. doi: 10.1371/journal.ppat.1006726. eCollection 2018 Jan.
PMID:29324905
8月23日: 小笠原
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.
Nat Immunol. 2018 Apr;19(4):386-396
PMID:29556002
10.1371/journal.ppat.101005