Lipoteichoic Acid From Lactobacillus Plantarum Inhibits Pam2CSK4-induced IL-8 Production in Human Intestinal Epithelial Cells

Noh SY, Kang S-S, Yun C-H, Han SH

Mol Immunol, 64 (1), 183-9 Mar 2015PMID: 25481370 DOI: 10.1016/j.molimm.2014.11.014


1月9日: 横田

Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages

Kawano M, Miyoshi M, Miyazaki T

Front Immunol, 10, 845 2019 Apr 17 eCollection 2019 PMID: 31057558 PMCID: PMC6478895 DOI: 10.3389/fimmu.2019.00845




12月19日: 福澤

Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane protein.

Huang L, Feng Y, Zong Z. J Antimicrob Chemother. 2019 Sep 1;74(9):2551-2558. doi: 10.1093/jac/dkz236.



Enterovirus pathogenesis requires the host methyltransferase SETD3.

Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE.

Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.


11月28日: 白石

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

Shao Y, Forster SC1, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.

Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.


11月21日: 桧山

Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.

Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.

Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.PMID: 30814593


10月10日: 小笠原

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.

Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24.PMID: 31235953


10月3日: 佐藤

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.PMID: 28614296


9月26日: 福澤

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nicoloff H, Hjort K, Levin BR, Andersson DI. Nat Microbiol. 2019 Mar;4(3):504-514. doi: 10.1038/s41564-018-0342-0. Epub 2019 Feb 11.

PMID: 30742072


9月19日: 横田

Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients.  Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR.  Sci Rep. 2019 Jul 22;9(1):10588. doi: 10.1038/s41598-019-46745-0. PMID: 31332258 


9月12日: 桧山

Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.

Ibana JA, Sherchand SP, Fontanilla FL, Nagamatsu T, Schust DJ, Quayle AJ, Aiyar A. Sci Rep. 2018 May 31;8(1):8476. doi: 10.1038/s41598-018-26765-y. PMID: 29855501


8月22日: 山本

NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11.PMID: 30982665


8月8日: 永島

Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis.Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF. Sci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038/s41598-018-32366-6.


7月25日: 白石

Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.

Taheri N, Mahmud AKMF, Sandblad L, Fällman M, Wai SN, Fahlgren A. Sci Rep. 2018 Nov 19;8(1):16996. doi: 10.1038/s41598-018-35409-0.



7月18日: 志賀

Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Takagi A, Yanagi H, Ozawa H, Uemura N, Nakajima S, Inoue K, Kawai T, Ohtsu T, Koga Y. Gastroenterol Res Pract. 2016;2016:7490452. doi: 10.1155/2016/7490452. Epub 2016 Jul 11.PMID: 27478434 


6月26日: 福澤

Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae.

Band VI, Crispell EK, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS.

Nat Microbiol. 2016 May 9;1(6):16053. doi: 10.1038/nmicrobiol.2016.53.PMID: 27572838 


6月19日: 小笠原

Airway response to respiratory syncytial virus has incidental antibacterial effects.

Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Nat Commun. 2019 May 17;10(1):2218. doi: 10.1038/s41467-019-10222-z. PMID: 31101811


5月29日: 永島

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Cario E, Gerken G, Podolsky DK. Gastroenterology. 2007 Apr;132(4):1359-74. Epub 2007 Feb 25. DOI:10.1053/j.gastro.2007.02.056. PMID:17408640


5月23日: 佐藤

Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131. Sarkar S, Hutton ML, Vagenas D, Ruter R, Schüller S, Lyras D, Schembri MA, Totsika M. J Infect Dis. 2018 Aug 14;218(6):979-990. doi: 10.1093/infdis/jiy031. PMID:29471349


5月16日: 桧山

 Fur Represses Adhesion to, Invasion of, and Intracellular Bacterial Community Formation within Bladder Epithelial Cells and Motility in Uropathogenic Escherichia coli. Kurabayashi K, Agata T, Asano H, Tomita H, Hirakawa H.Infect Immun. 2016 Oct 17;84(11):3220-3231. doi: 10.1128/IAI.00369-16. Print 2016 Nov. PMID:27572332


4月18日: 山本

Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT.Cell Rep. 2018 Mar 20;22(12):3304-3314. doi:10.1016/j.celrep.2018.03.003.




Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice.

Ohsawa K, Uchida N, Ohki K, Yokogoshi H. Int J Food Sci Nutr. 2018 Feb;69(1):33-45.

doi: 10.1080/09637486.2017.1324564. Epub 2017 May 23.



Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex. Guérin F, Isnard C, Cattoir V, Giard JC. Antimicrob Agents Chemother. 2015 Dec;59(12):7753-61. doi: 10.1128/AAC.01729-15. Epub 2015 Oct 5.PMID: 26438498



A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. PMID:30675064 



Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.

Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671. doi: 10.1073/pnas.1809100115.

PMID: 30352847




Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.

Science. 2018 Apr 13;360(6385):204-208.

PMID: 29650672



Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.

Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C.

Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.

PMID: 29795541



Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.

Kamdar K, Johnson AMF, Chac D, Myers K, Kulur V, Truevillian K, DePaolo RW.

J Immunol. 2018 Jul 1;201(1):230-242. doi: 10.4049/jimmunol.1701216. Epub 2018 May 23.

PMID: 29794015



The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.

Ding B, Zhang L, Li Z, Zhong Y, Tang Q, Qin Y, Chen M.

Cell Host Microbe. 2017 Apr 12;21(4):538-547.e4. doi: 10.1016/j.chom.2017.03.004.

PMID: 28407488



Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.

Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T.

PLoS Pathog. 2018 Apr 5;14(4):e1006955. doi: 10.1371/journal.ppat.1006955. eCollection 2018 Apr.

PMID: 29621339 


10月11日: 桧山

Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent UrinaryTract Infection.

 Ali ASM, Mowbray C, Lanz M, Stanton A, Bowen S, Varley CL, Hilton P, Brown K, Robson W, Southgate J, Aldridge PD, Tyson-Capper A, Abraham S, Pickard RS, Hall J.

Sci Rep. 2017 Sep 8;7(1):11039. doi: 10.1038/s41598-017-10445-4.

PMID: 28887442


9月27日: 白石

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW

Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. Erratum in: Nature. 2018 Aug 29

PMID: 30089902


9月20日: 山本

Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.

Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.

PMID: 30209367


9月6日: 佐藤

Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.

Shaik S, Ranjan A, Tiwari SK, Hussain A, Nandanwar N, Kumar N, Jadhav S, Semmler T, Baddam R, Islam MA, Alam M, Wieler LH, Watanabe H, Ahmed N

MBio. 2017 Oct 24;8(5). pii: e01596-17. doi: 10.1128/mBio.01596-17.

PMID: 29066550


8月30日: 本田

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.

Sela U, Euler CW, Correa da Rosa J, Fischetti VA.

PLoS Pathog. 2018 Jan 11;14(1):e1006726. doi: 10.1371/journal.ppat.1006726. eCollection 2018 Jan.



8月23日: 小笠原

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.

Nat Immunol. 2018 Apr;19(4):386-396