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9月16日: 谷向

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A condensate-hardening drug blocks RSV replication in vivo,

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Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

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8月5日: 上村

Kasturi Banerjee,Michael P. Motley,Elizabeth Diago-Navarro, Bettina C. Fries

”Serum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected Patients”

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Lili Chan , Kumardeep Chaudhary , Aparna Saha, et al.,

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Li Wang , Qihui Zhu, Kunlun Xiang, Yaling Zhang, Baocun Li , Xin Yu, Guang Yang , Chungen Liang ,

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Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor

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Sang-Sang Park, Norberto Gonzalez-Juarbe, Eriel Martínez, Joanetha Yvette Hale, Yi-Han Lin, Joshua T Huffines, Katherine L Kruckow, David E Briles, Carlos J Orihuela

Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence

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Zharko Daniloski, Tristan X Jordan , Hans-Hermann Wessels, Daisy A Hoagland, Silva Kasela, Mateusz Legut, Silas Maniatis , Eleni P Mimitou, Lu Lu, Evan Geller, Oded Danziger , Brad R Rosenberg, Hemali Phatnani, Peter Smibert, Tuuli Lappalainen, Benjamin R tenOever, Neville E Sanjana

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

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Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z.

Identification of novel mobile colistin resistance gene mcr-10.

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Jamie L Dombach, Joaquin L J Quintana, Toni A Nagy, Chun Wan, Amy L Crooks, Haijia Yu, Chih-Chia Su, Edward W Yu, Jingshi Shen, Corrella S Detweiler. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog. 2020 Dec 8;16(12):e1009119. PMID: 33290418



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Andreas Greinacher, Thomas Thiele, Theodore E Warkentin, Karin Weisser, Paul A Kyrle, Sabine Eichinger

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Michael Hulko, Verena Dietrich, Ilona Koch, Alexander Gekeler, Michael

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Imane El Meouche and Mary J Dunlop

Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation

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Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B.

Sorting nexin 5 mediates virus-induced autophagy and immunity.

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Anthony R. Hesser, Kaitlin Schaefer, Wonsik Lee, and Suzanne Walker.

Lipoteichoic acid polymer length is determined by competition between free starter units.

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3月18日:横田 「alpha-Gal syndrome」

Crispell G, Commins SP, Archer-Hartman SA, Choudhary S, Dharmarajan G, Azadi P, Karim S.

Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy.

Front Immunol. 2019 May 17;10:1056. doi: 10.3389/fimmu.2019.01056.



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Sex differences in immune responses that underlie COVID-19 disease outcome.Nature. 2020 Dec;588(7837):315-320.PMID: 32846427

Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A; Yale IMPACT Team, Herbst R, Shaw AC, Medzhitov R, Schulz WL, Grubaugh ND, Dela Cruz C, Farhadian S, Ko AI, Omer SB, Iwasaki A.

Longitudinal analyses reveal immunological misfiring in severe COVID-19.Nature. 2020 Aug;584(7821):463-469.PMID: 32717743



James K Martin, Joseph P Sheehan, Benjamin P Bratton, Gabriel M Moore, André Mateus, Sophia Hsin-Jung Li, Hahn Kim, Joshua D Rabinowitz, Athanasios Typas, Mikhail M Savitski, Maxwell Z Wilson, Zemer Gitai

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

Cell. 2020 Jun 25;181(7):1518-1532.e14. doi: 10.1016/j.cell.2020.05.005. Epub 2020 Jun 3. PMID: 32497502



Xishao Xie, Junni Wang, Shilong Xiang, Zhimin Chen, Xiaohui Zhang, Jianghua Chen

Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis.

BMC Nephrol, 2019, 20(1):128, PMID 30975091



Yun Kit Yeoh et al., Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.

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1月21 日: 福澤

Beyrouthy R, Barets M, Marion E, Dananché C, Dauwalder O, Robin F, Gauthier L, Jousse A, Dortet L, Guérin F, Bénet T, Cassier P, Vanhems P, Bonnet R. 2018. Novel Enterobacter lineage as leading cause of nosocomial outbreak involving carbapenemase-producing strains.

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1月14日: 上村

Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker

Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

mBio, 2019 Sep 17;10(5):e01822-19. doi: 10.1128/mBio.01822-19.



12月17日: 山本

Ghosh S. et al

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

Cell, 2020 Dec 10;183(6):1520-1535.e14., doi: 10.1016/j.cell.2020.10.039. Epub 2020 Oct 27.



Kyong-Su Park, Jaewook Lee, Changjin Lee, Hyun Taek Park, Jung-Wook Kim, Oh Youn Kim, Sae Rom Kim, Madeleine Rådinge, Hoe-Yune Jung, Jaesung Park, Jan Lötvall, and Yong Song Gho

Sepsis-like systemic inflammation induced by nano-sized extracellular vesicles from feces

Front Microbioi. 9:1735 (2018)


12月3日: 横田

Bradshaw JL, Pipkins HR, Keller LE, Pendarvis JK, McDaniel LS.

Mucosal Infections and Invasive Potential of Nonencapsulated Streptococcus pneumoniae Are Enhanced by Oligopeptide Binding Proteins AliC and AliD.

mBio. 2018 Jan 16;9(1):e02097-17. doi: 10.1128/mBio.02097-17. PMID: 29339428



Shazad Mushtaq, Rosy Reynolds, Michael C Gilmore, Olubukola Esho, Rachael Adkin, Inmaculada García-Romero, Aiysha Chaudhry, Carolyne Horner, Toby L Bartholomew, Miguel A Valvano, Magdalena Dry, John Murray, Bruno Pichon, David M Livermore

Inherent colistin resistance in genogroups of the Enterobacter cloacae complex: epidemiological, genetic and biochemical analysis from the BSAC Resistance Surveillance Programme

J Antimicrob Chemother, 2020 Sep 1;75(9):2452-2461.



Habibi MS, Thwaites RS, Chang M, Jozwik A, Paras A, Kirsebom F, Varese A, Owen A, Cuthbertson L, James P, Tunstall T, Nickle D, Hansel TT, Moffatt MF, Johansson C, Chiu C, Openshaw PJM.

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection.

Science. 2020 Oct 9;370(6513):eaba9301. doi: 10.1126/science.aba9301. PMID: 33033192


10月15日: 上村 

Michelle K. Paczosa,Rebecca J. Silver, Anne L. McCabe,Albert K. Tai,Colin H. McLeish,David W. Lazinski,Joan MecsasTransposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice

Infect Immun. 2020 Apr; 88(4): e00034-20. doi: 10.1128/IAI.00034-20.PMID: 31988174



Ákos Nyerges, Bálint Csörgő , Gábor Draskovits, Bálint Kintses, Petra Szili, Györgyi Ferenc, Tamás Révész, Eszter Ari, István Nagy , Balázs Bálint , Bálint Márk Vásárhelyi , Péter Bihari , Mónika Számel, Dávid Balogh, Henrietta Papp, Dorottya Kalapis, Balázs Papp, Csaba Pál Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. doi: 10.1073/pnas.1801646115.Epub 2018 Jun 5.PMID: 29871954



Maurizio Bossola, Maurizio Sanguinetti, Donata Scribano, Cecilia Zuppi, Stefania Giungi, Giovanna Luciani, Riccardo Torelli, Brunella Posteraro, Giovanni Fadda, Luigi Tazza

Circulating bacterial-derived DNA fragments and markers of inflammation in chronic hemodialysis patients

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9月24日: 福澤

Joseph D. Lutgring,Anny Kim,Davina Campbell,Maria Karlsson,Allison C. Brown,Eileen M. Burd.

Evaluation of the MicroScan Colistin Well and Gradient Diffusion Strips for Colistin Susceptibility Testing in Enterobacteriaceae. Journal of Clinical Microbiology 2019 57:e01866-18.


Griffiths CD, Bilawchuk LM, McDonough JE, Jamieson KC, Elawar F, Cen Y, Duan W, Lin C, Song H, Casanova JL, Ogg S, Jensen LD, Thienpont B, Kumar A, Hobman TC, Proud D, Moraes TJ, Marchant DJ.

IGF1R is an entry receptor for respiratory syncytial virus

Nature. 2020 Jul;583(7817):615-619. doi: 10.1038/s41586-020-2369-7. Epub 2020 Jun 3. PMID: 32494007


C. K. Stein-Thoeringer, K. B. Nichols, A. Lazrak, M. D. Docampo, A. E. Slingerland, J. B. Slingerland, A. G. Clurman, G. Armijo, A. L. C. Gomes, Y. Shono, A. Staffas, M. Burgos da Silva, S. M. Devlin, K. A. Markey, D. Bajic, R. Pinedo, A. Tsakmaklis, E. R. Littmann, A. Pastore, Y. Taur, S. Monette, M. E. Arcila, A. J. Pickard, M. Maloy, R. J. Wright, L. A. Amoretti, E. Fontana, D. Pham, M. A. Jamal, D. Weber, A. D. Sung, D. Hashimoto, C. Scheid, J. B. Xavier, J. A. Messina, K. Romero, M. Lew, A. Bush, L. Bohannon, K. Hayasaka, Y. Hasegawa, M. J. G. T. Vehreschild, J. R. Cross, D. M. Ponce, M. A. Perales, S. A. Giralt, R. R. Jenq, T. Teshima, E. Holler, N. J. Chao, E. G. Pamer, J. U. Peled, M. R. M. van den Brink

Lactose drives Enterococcus expansion to promote graft-versus-host disease.

Science. 366:1143-1149 (2019)



A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

Kimberly A. Walker,corresponding authora Taryn A. Miner,a Michelle Palacios, Dominika Trzilova, Daniel R. Frederick, Christopher A. Broberg, Victoria E. Sepúlveda, Joshua D. Quinn, and Virginia L. Millera

mBio. 2019 Mar-Apr; 10(2): e00089-19. doi: 10.1128/mBio.00089-19 PMID: 30914502



MgrB Inactivation Is Responsible for Acquired Resistance to Colistin in Enterobacter hormaechei subsp. steigerwaltii.

Amel Mhaya, Dominique Bégu,Slim Tounsi,Corinne Arpin.

Antimicrobial Agents and Chemotherapy PMID: 32253218 PMCID: PMC7269514 DOI: 10.1128/AAC.00128-20



p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.

Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.

J Clin Invest. 2019 Nov 1;129(11):4875-4884. doi: 10.1172/JCI128626. PMID: 31430261



Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

Christoph M Ernst, Julian R Braxton, Carlos A Rodriguez-Osorio, Anna P Zagieboylo, Li Li, Alejandro Pironti , Abigail L Manson , Anil V Nair , Maura Benson, Kaelyn Cummins, Anne E Clatworthy, Ashlee M Earl, Lisa A Cosimi, Deborah T Hung

Nat Med. 2020 May;26(5):705-711. doi: 10.1038/s41591-020-0825-4. PMID: 32284589



Colistin Heteroresistance in Enterobacter Cloacae Is Regulated by PhoPQ-dependent 4-amino-4-deoxy-l-arabinose Addition to Lipid A

Katie N Kang, Dustin R Klein, Misha I Kazi, François Guérin, Vincent Cattoir, Jennifer S Brodbelt, Joseph M Boll

Mol Microbiol., 2019, PMID: 30873646


7月1日:福澤 自粛期間中の課題の論文

Unstable Tandem Gene Amplification Generates Heteroresistance (Variation in Resistance Within a Population) to Colistin in Salmonella Enterica,

Karin Hjort, Hervé Nicoloff, Dan I Andersson

Mol Microbiol., 2016, PMID: 27381382



The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity.

Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S.

J Bacteriol. 2020. doi: 10.1128/JB.00149-20. PMID: 32482719




SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S.

Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052.



Mechanisms and clinical relevanceof bacterial heteroresistance

Andersson DI, Nicoloff H, Hjort K.

Nat Rev Microbiol. 2019 Aug;17(8):479-496. doi: 10.1038/s41579-019-0218-1. Epub 2019 Jun 24. Review.



Staphylococcus aureus induces IL-8 expression through its lipoproteins in the human intestinal epithelial cell, Caco-2.

Kang SS, Noh SY, Park OJ, Yun CH, Han SH.

Cytokine. 2015 Sep;75(1):174-80. doi: 10.1016/j.cyto.2015.04.017. PMID: 25982554



An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.

Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori MA, Tangy F, Stavru F, Bessonov S, Dessen A, Muchardt C, Lebreton A, Komarova AV, Cossart P.

Cell Host Microbe. 2019 26(6):823-835. PMID: 31761719; PubMed Central PMCID: PMC6907008.



Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale G, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.

Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. PMID: 31645764



Weak Agonistic LPS Restores Intestinal Immune Homeostasis.

Steimle A, Michaelis L, Di Lorenzo F, Kliem T, Münzner T, Maerz JK, Schäfer A, Lange A, Parusel R, Gronbach K, Fuchs K, Silipo A, Öz HH, Pichler BJ, Autenrieth IB, Molinaro A, Frick JS

Mol Ther. 2019 Nov 6;27(11):1974-1991. PMID:31416777. doi: 10.1016/j.ymthe.2019.07.007. Epub 2019 Jul 19.



Lipoteichoic Acid From Lactobacillus Plantarum Inhibits Pam2CSK4-induced IL-8 Production in Human Intestinal Epithelial Cells

Noh SY, Kang S-S, Yun C-H, Han SH

Mol Immunol, 64 (1), 183-9 Mar 2015PMID: 25481370 DOI: 10.1016/j.molimm.2014.11.014


1月9日: 横田

Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages

Kawano M, Miyoshi M, Miyazaki T

Front Immunol, 10, 845 2019 Apr 17 eCollection 2019 PMID: 31057558 PMCID: PMC6478895 DOI: 10.3389/fimmu.2019.00845




12月19日: 福澤

Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane protein.

Huang L, Feng Y, Zong Z. J Antimicrob Chemother. 2019 Sep 1;74(9):2551-2558. doi: 10.1093/jac/dkz236.



Enterovirus pathogenesis requires the host methyltransferase SETD3.

Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE.

Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.


11月28日: 白石

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

Shao Y, Forster SC1, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.

Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.


11月21日: 桧山

Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.

Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.

Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.PMID: 30814593


10月10日: 小笠原

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.

Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24.PMID: 31235953


10月3日: 佐藤

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.PMID: 28614296


9月26日: 福澤

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nicoloff H, Hjort K, Levin BR, Andersson DI. Nat Microbiol. 2019 Mar;4(3):504-514. doi: 10.1038/s41564-018-0342-0. Epub 2019 Feb 11.

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9月19日: 横田

Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients. Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR. Sci Rep. 2019 Jul 22;9(1):10588. doi: 10.1038/s41598-019-46745-0. PMID: 31332258


9月12日: 桧山

Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.

Ibana JA, Sherchand SP, Fontanilla FL, Nagamatsu T, Schust DJ, Quayle AJ, Aiyar A. Sci Rep. 2018 May 31;8(1):8476. doi: 10.1038/s41598-018-26765-y. PMID: 29855501


8月22日: 山本

NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11.PMID: 30982665


8月8日: 永島

Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis.Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF. Sci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038/s41598-018-32366-6.


7月25日: 白石

Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.

Taheri N, Mahmud AKMF, Sandblad L, Fällman M, Wai SN, Fahlgren A. Sci Rep. 2018 Nov 19;8(1):16996. doi: 10.1038/s41598-018-35409-0.



7月18日: 志賀

Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Takagi A, Yanagi H, Ozawa H, Uemura N, Nakajima S, Inoue K, Kawai T, Ohtsu T, Koga Y. Gastroenterol Res Pract. 2016;2016:7490452. doi: 10.1155/2016/7490452. Epub 2016 Jul 11.PMID: 27478434


6月26日: 福澤

Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae.

Band VI, Crispell EK, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS.

Nat Microbiol. 2016 May 9;1(6):16053. doi: 10.1038/nmicrobiol.2016.53.PMID: 27572838


6月19日: 小笠原

Airway response to respiratory syncytial virus has incidental antibacterial effects.

Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Nat Commun. 2019 May 17;10(1):2218. doi: 10.1038/s41467-019-10222-z. PMID: 31101811


5月29日: 永島

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Cario E, Gerken G, Podolsky DK. Gastroenterology. 2007 Apr;132(4):1359-74. Epub 2007 Feb 25. DOI:10.1053/j.gastro.2007.02.056. PMID:17408640


5月23日: 佐藤

Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131. Sarkar S, Hutton ML, Vagenas D, Ruter R, Schüller S, Lyras D, Schembri MA, Totsika M. J Infect Dis. 2018 Aug 14;218(6):979-990. doi: 10.1093/infdis/jiy031. PMID:29471349


5月16日: 桧山

Fur Represses Adhesion to, Invasion of, and Intracellular Bacterial Community Formation within Bladder Epithelial Cells and Motility in Uropathogenic Escherichia coli. Kurabayashi K, Agata T, Asano H, Tomita H, Hirakawa H.Infect Immun. 2016 Oct 17;84(11):3220-3231. doi: 10.1128/IAI.00369-16. Print 2016 Nov. PMID:27572332


4月18日: 山本

Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT.Cell Rep. 2018 Mar 20;22(12):3304-3314. doi:10.1016/j.celrep.2018.03.003.




Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice.

Ohsawa K, Uchida N, Ohki K, Yokogoshi H. Int J Food Sci Nutr. 2018 Feb;69(1):33-45.

doi: 10.1080/09637486.2017.1324564. Epub 2017 May 23.



Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex. Guérin F, Isnard C, Cattoir V, Giard JC. Antimicrob Agents Chemother. 2015 Dec;59(12):7753-61. doi: 10.1128/AAC.01729-15. Epub 2015 Oct 5.PMID: 26438498



A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. PMID:30675064



Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.

Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671. doi: 10.1073/pnas.1809100115.

PMID: 30352847




Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.

Science. 2018 Apr 13;360(6385):204-208.

PMID: 29650672



Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.

Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C.

Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.

PMID: 29795541



Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.

Kamdar K, Johnson AMF, Chac D, Myers K, Kulur V, Truevillian K, DePaolo RW.

J Immunol. 2018 Jul 1;201(1):230-242. doi: 10.4049/jimmunol.1701216. Epub 2018 May 23.

PMID: 29794015



The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.

Ding B, Zhang L, Li Z, Zhong Y, Tang Q, Qin Y, Chen M.

Cell Host Microbe. 2017 Apr 12;21(4):538-547.e4. doi: 10.1016/j.chom.2017.03.004.

PMID: 28407488



Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.

Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T.

PLoS Pathog. 2018 Apr 5;14(4):e1006955. doi: 10.1371/journal.ppat.1006955. eCollection 2018 Apr.

PMID: 29621339


10月11日: 桧山

Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent UrinaryTract Infection.

Ali ASM, Mowbray C, Lanz M, Stanton A, Bowen S, Varley CL, Hilton P, Brown K, Robson W, Southgate J, Aldridge PD, Tyson-Capper A, Abraham S, Pickard RS, Hall J.

Sci Rep. 2017 Sep 8;7(1):11039. doi: 10.1038/s41598-017-10445-4.

PMID: 28887442


9月27日: 白石

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW

Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. Erratum in: Nature. 2018 Aug 29

PMID: 30089902


9月20日: 山本

Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.

Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.

PMID: 30209367


9月6日: 佐藤

Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.

Shaik S, Ranjan A, Tiwari SK, Hussain A, Nandanwar N, Kumar N, Jadhav S, Semmler T, Baddam R, Islam MA, Alam M, Wieler LH, Watanabe H, Ahmed N

MBio. 2017 Oct 24;8(5). pii: e01596-17. doi: 10.1128/mBio.01596-17.

PMID: 29066550


8月30日: 本田

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.

Sela U, Euler CW, Correa da Rosa J, Fischetti VA.

PLoS Pathog. 2018 Jan 11;14(1):e1006726. doi: 10.1371/journal.ppat.1006726. eCollection 2018 Jan.



8月23日: 小笠原

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.

Nat Immunol. 2018 Apr;19(4):386-396